Podocytes in aminonucleoside glomerulonephritis investigated ultrastructurally with concanavalin A.
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چکیده
منابع مشابه
Puromycin aminonucleoside modulates p130Cas of podocytes
PURPOSE Puromycin aminonucleoside (PAN) specifically injures podocytes, leading to foot process effacement, actin cytoskeleton disorganization, and abnormal distribution of slit diaphragm proteins. p130Cas is a docking protein connecting F-actin fibers to the glomerular basement membrane (GBM) and adapter proteins in glomerular epithelial cells (GEpCs; podocytes). We investigated the changes in...
متن کاملDemonstration of percellular channels in glamerular podocytes in aminonucleoside nephosis.
Nephrotic syndrome was experimentally induced by a single i.v. injection of puromyein. Permeability of the visceral epithelial wall of glomeruli was examined with electron microscope. 30-60 seconds prior to fixation, ferritin solution was injected into the urinary space of superficially located glomeruli either by direct micropuncture of the urinary space or by retrograde filling of the urinary...
متن کاملExperimental glomerulonephritis in rats produced with soluble antigen-antibody complexes after pretreatment with aminonucleoside.
The pathogenesis of human glomerulonephritis has not been throughly recognized in spite of many extensive experimental examinations and clinical observations. With regard to experimental glomerulonephritis, MASUGI's nephritis and glomerulonephritis in serum sickness has been believed to play an important role. In serum sickness, glomerulonephritis develops during the immune phase of antigen eli...
متن کاملCadherin and catenin staining in podocytes in development and puromycin aminonucleoside nephrosis.
Podocytes have been shown to express classical cadherins in the early stage of glomerulogenesis, but it remains unclear whether podocytes in normal and pathological conditions express cadherins in the adult stage. To address this question, rat podocytes in the neonate, the adult and in puromycin aminonucleoside (PAN) nephrosis were examined by immunofluorescence microscopy using antibodies agai...
متن کاملNovel expression of sodium/myo-inositol co-transporter in podocytes in puromycin aminonucleoside nephrosis.
BACKGROUND How podocytes respond to injury is poorly understood, although podocyte injury in the glomerulus has been proposed as the crucial mechanism in the pathogenesis of proteinuria and focal segmental glomerulosclerosis. An increase in sodium/myo-inositol co-transporter (SMIT) transcripts, an osmoprotective gene, has been demonstrated in a variety of brain injury models. In the present stu...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 1979
ISSN: 0022-1554,1551-5044
DOI: 10.1177/27.12.521617